Woman holding a bottle of Maelove Peptide Squad serum
Beauty Awards winner
4.7/5 based on 1,186+ verified reviews

4 Peptides. 4 Ways to Fight Wrinkles.

Most peptide serums only use one or two. Peptide Squad combines all four wrinkle-fighting types in one lightweight serum to target signs of aging.


  • Restore firmness · Copper peptides (GHK-Cu)
  • Build collagen · Matrixyl 3000
  • Soften expression lines · Argireline
  • Prevent collagen breakdown · Rice peptides
Try Peptide Squad

100-Day Money-Back Guarantee

Free Shipping

  • Dermatologist-Tested
  • Safe for Sensitive Skin
  • Boosts Collagen Production
  • Made in the USA
Trusted by Dermatologists

Most brands follow trends. We follow the science.

Copper Peptide / GHK-Cu

Copper Peptide / GHK-Cu

RENEWAL SUPPORT

A carrier peptide that delivers copper to skin cells, supporting skin renewal.

Argireline

Argireline

EXPRESSION LINE SUPPORT

A “botox-like” peptide that helps soften the look of expression lines around the eyes and forehead.

Matrixyl 3000

Matrixyl 3000

FIRMNESS SUPPORT

A signal peptide that supports collagen and elastin production, for skin that looks firmer over time.

Rice Peptides

Rice Peptides

COLLAGEN PROTECTION

Enzyme-inhibiting peptides that help protect the collagen you have from breaking down.

4.7/5 based on 1,186+ verified reviews

 Trusted by Thousands of Dermatologists Nationwide

 Trusted by Thousands of Dermatologists Nationwide

Jelena Eddy, PA-Cdermanddose Dermatology
Dr. Riana D. Sanyal, MDriana.md
Dr. Allison Sindle, MDdermallimd FAAD
Dr. Yssra Soliman, MDdryssra FAAD
Ami Dalal, PA-Cdermpa23
Kelsey Chung, NPkelsey_lpaesthetics
Morgan Amigo, MDmorganamigomd FAAD
Dr. Teekz | Skin Care Expert & Doctordermdrteekz
Lauren Plasky, PA-Clauren_does_derm

"Not all peptide serums are created equal. Maelove's Peptide Squad has four times the peptide power, with four distinct types of peptides that allow our body to increase its natural production of collagen."

Morgan Amigo, MD

"I love this formula. I also love that I have all my peptides covered every time I use it. It layers beautifully under moisturizer and sunscreen. And it even plays well with certain antioxidant and vitamin C serums, like Maelove's Glow Maker."

Riana D. Sanyal, MD

"I love this blend of peptides because they are effective, easy to tolerate, and compatible with most other active ingredients."

Meredith Price, MD

"It's super, super smooth and very hydrating, very moisturizing, so it really does help prevent any irritation to the skin barrier.”

Ritu Saini, MD

"Adding Peptide Squad to my routine has made the biggest difference in how my skin feels."

Jessica Hoy, MD

"I use it [Peptide Squad] twice a day."

Avnee Shah, MD

"One thing people don't realize about peptide serums is that formulation and pairing really matter. What I like about Maelove's Peptide Squad serum is that it combines multiple peptides that work through different pathways."

Kabir Al-Tariq, MD

"Science shows peptides help boost collagen, smooth fine lines, and strengthen your skin barrier, giving a firmer, healthier glow. That's why us dermatologists love the Maelove Peptide Squad Serum. It's smart science in a bottle, no hype required."

Lauren Penzi, MD

"Peptide Squad contains Argireline, which relaxes facial muscles and helps reduce wrinkles."

Mansha Sethi, MD

"It’s super safe to use, whether it's in addition to your retinol or as a replacement for retinol to help with anti-aging on the skin."

Allison Sindle, MD

"Peptide Squad combines four different types of peptides: copper peptides to build collagen, Argireline to relax fine expression lines, Matrixyl 3000 to firm the skin, and rice peptides to prevent collagen breakdown. It hydrates like a dream and supports a healthy skin barrier.

Olnita Martini, MD & Danielle Duffle, MD

"Signal peptides essentially act as messengers in the skin and tell our skin cells to produce more collagen and elastin fibers. Copper peptides work a little bit differently. They're essentially mini proteins that carry copper ions to our skin cells, which then our skin cells use to make collagen."

Kelsey Hayes, DO

"I love peptides. I think that they are the future of skincare. So I recommend you all try the Maelove Peptide Squad Serum for plumper, healthier skin."

Teekz Yenpasook, MD

"Copper peptides promote collagen production while aggressively fighting inflammation and oxidative damage without the irritation of retinoids."

Jonny Hatch, DO

"Think of these peptides as little messengers that support collagen and keep skin firm."

Christina Huang, MD

"Peptide Squad was named the Best Firming Serum in Cosmopolitan's Clean Beauty Awards 2025. The four-peptide complex with bonus ingredients like niacinamide, turmeric, and jojoba oil."

Heidi K. Anderson, MD

"Matrixyl 3000 and copper peptides are signal messengers that directly stimulate collagen synthesis, working on a cellular level to firm and renew skin texture."

Renata Block, PA-C
Dr. Maren Locke
Dr. Maren LockeOcala, FL
Dr. Charles Puza
Dr. Charles PuzaNew York, NY
Dr. Avnee Shah
Dr. Avnee ShahVerona, NJ
Dr. Andrew Park
Dr. Andrew ParkLos Angeles, CA
Dr. Luke Maxfield
Dr. Luke MaxfieldChattanooga, TN
Dr. Attiya Haroon
Dr. Attiya HaroonFresno, CA
Dr. Sam Ellis
Dr. Sam EllisDanville, CA
Dr. Rehan Karim
Dr. Rehan KarimDallas, TX
Dr. Sophia Akhiyat
Dr. Sophia AkhiyatSan Diego, CA
Dr. Mary Haver
Dr. Mary HaverGalveston, TX
Dr. Daniel Sugai
Dr. Daniel SugaiBellevue, WA
Dr. Tia Paul
Dr. Tia PaulNewport Beach, CA
Dr. Scott Walter
Dr. Scott WalterGolden, CO
Dr. Chris Tomas
Dr. Chris TomasGlendora, CA
Dr. Dylan Greeney
Dr. Dylan GreeneyEvansville, IN
Dr. Allison Sindle
Dr. Allison SindleSikeston, MO
Dr. Meredith Price
Dr. Meredith PriceGrosse Pointe, MI
Dr. Rohan Shah
Dr. Rohan ShahPrinceton, NJ
Dr. Mark Strom
Dr. Mark StromBrooklyn, NY
BestsellerPeptide Squad Collagen Renewal Serum
0:00
Peptide Squad Collagen Renewal Serum
0:00
0:00
0:00
4.7/5 based on 1,186+ verified reviews

Peptide Squad Collagen Renewal Serum

Award “Best Firming Serum” - Cosmopolitan's Clean Beauty Awards

Your skin, but firmer.

Collagen production declines with age, and skin stops bouncing back the way it used to. Peptide Squad combines four peptide technologies that support collagen, soften the look of expression lines, and help skin look firmer over time.

100-DayMoney-Back

Free Shippinglimited offer

Made in USAFDA-Registered Facility

4.7/5 rating1,186 reviews

How to use

Morning and night
Apply a thin layer to your face, neck, and chest. Massage in until absorbed, then follow with moisturizer.

Don't skip your neck and chest
They're just as exposed to sun and aging as your face, and they respond well to peptides.

First-time users
You may notice slight tingling or temporary numbing from the Argireline peptide. This is normal and fades as your skin adjusts.

Layering with other products

  1. Peptide Squad plays well with all Maelove products
  2. Apply thinnest to thickest, waiting one minute between layers
  3. Safe to use with vitamin C (morning) and retinoids (night)
Ingredient

Main ingredients

Copper Tripeptide-1, Matrixyl 3000, Argireline, Rice Peptides

Supporting ingredients

Niacinamide, Panthenol, Ceramides, Turmeric, Jojoba Oil, Hyaluronic Acid, Glycerin

Full ingredients list

Aqua (Water), Glycerin, Propanediol, Caprylyl Glycol, Niacinamide, Panthenol (D), Simmondsia Chinensis (Jojoba) Seed Oil, Copper Tripeptide-1, Ceramide EOP, Ceramide NP, Acetyl Hexapeptide-8, Ceramide AP, Allantoin, Sodium Hyaluronate (L), Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Hydrolyzed Rice Protein, Aloe Barbadensis Flower Extract, Bisabolol (L-alpha), Curcuma Longa (Turmeric) Root Extract, Camellia Sinensis (Green Tea) Leaf Extract, Melia Azadirachta (Neem) Leaf Extract, Melia Azadirachta (Neem) Flower Extract, Hamamelis Virginiana (Witch Hazel) Water, Chondrus Crispus (Carrageenan) Extract, Glycine, Pullulan, Sodium Lactate, Coccinia Indica Fruit Extract, Cholesterol, Carbomer, Solanum Melongena (Eggplant) Fruit Extract, Dimethicone, Butylene Glycol, Polysorbate 20, Sodium Gluconate, Madecassoside, Hydrolyzed Gardenia Florida Extract, Phytosphingosine, Corallina Officinalis Extract, Ocimum Sanctum Leaf Extract, Sodium Lauroyl Lactylate, Sclerotium Gum, Maltodextrin, Ethylhexylglycerin, Proline, Xanthan Gum, Sodium PCA, Sodium Hydroxide, Lecithin, Phenoxyethanol, Citric Acid, Alcohol, Alcohol Denat

Shipping & Returns
  • Limited time - Free US Shipping
  • 100-Day Guarantee: Try it risk-free for 100 days
  • Ships from an FDA-registered facility in Northern California

Four Peptide Classes, Four Ways to Fight Visible Aging.

Most serums lean on one or two peptides. Peptide Squad is one of the only formulas with all four science-backed classes, each targeting a different driver of aging skin.

  1. Signal Peptides - Matrixyl 3000

    Two collagen-building signal peptides that tell your skin to produce more collagen and elastin, helping rebuild firmness from within.

  2. Carrier Peptides - Copper Tripeptide-1 (GHK-Cu)

    Delivers stabilised copper your skin uses for collagen synthesis and repair. It's also what gives the serum its signature blue hue.

  3. Neurotransmitter Inhibitors - Argireline

    Gently relaxes the repetitive muscle movements that etch expression lines around the eyes and forehead, softening their appearance over time.

  4. Enzyme Inhibitors - Rice Peptides

    Help block the enzymes (MMPs) that break down the collagen you already have, so your skin holds onto its structure for longer.

Results you can see and feel

5 out of 5 stars

My only regret is that I didn’t find it sooner

I'm 46 and my skin is glowy and bouncy and looks better than it did in my 30s! This serum is amazing and has quickly become my favourite. I use it morning and night as part of my overall routine.

Tamara M.Verified Buyer
5 out of 5 stars

My fine lines are not as prominent

I've been hearing about this serum from YouTube bloggers and such, so I finally decided to give it a try. I'm so glad I did, as I'm having great results. My skin seems firmer and brighter, and my fine lines are less prominent. I am very, very pleased and I will definitely repurchase.

Joyce T.Verified Buyer
5 out of 5 stars

I would tell my 30 year old self to use this serum.

At 64, I would love a product to turn back time, but the best I can do moving forward is to do no harm. This serum does not flare my rosacea. Layers well. Sinks in beautifully.

Melody B.Verified Buyer
5 out of 5 stars

Amazing

This little powerhouse peptide serum has replaced several bottles of high-end products, and I think it even works better! I have it on auto subscribe now so I never run out!

Shawnah C.Verified Buyer
5 out of 5 stars

Love this!

I'm a pilot, so I'm constantly in very dry conditions in airplanes and hotels, and I get a lot of sun damage from being in the sun at high altitudes. With Peptide Squad, my skin doesn't dry out all day, and I have noticed a reduction in my fine lines (age 40).

Jenny M.Verified Buyer
5 out of 5 stars

The results appeared almost immediately!

I'm in love with this peptide serum! I have very sensitive skin and this serum works perfectly on me and does not cause irritation. My skin is much firmer and smoother since adding it to my routine. I'm a fan forever!

Shannon A.Verified Buyer
5 out of 5 stars

Amazing product and quality

I love that this serum has the major 4 peptides in it along with other great skin ingredients like niacinamide and vitamin B5. Its blue color with the natural copper is also interesting. I love how it makes my skin look.

Elena A.Verified Buyer
5 out of 5 stars

Seeing great results

I have been using this product for over a year. I am 61 and have seen a huge improvement in fines lines. Love this product!!!

Nancy S.Verified Buyer
5 out of 5 stars

I do not use Botox or fillers.

I love this product! I’m going to be 65 in November and this works very well. I do not use Botox or fillers. My lines are more faint and my skin feels great.

Kathy S.Verified Buyer
5 out of 5 stars

My skin feels and looks great

I've been using the Peptide Squad with Glow Maker for a few months now. My skin feels much smoother and softer than it has in a long time. And the lines in my neck & chest are getting less noticeable.

Betty A. W.Verified Buyer
5 out of 5 stars

Love Peptide Squad!

I was surprised at how much I love the Peptide Squad. My face feels tighter, and my complexion looks a little better and more glowy. I've only been using it about 1 month now.

Jennifer T.Verified Buyer
  • Dermatologist-Tested
  • Safe for Sensitive Skin
  • Boosts Collagen Production
  • Made in the USA
4.7/5 based on 1,186+ verified reviews

You Deserve a Solution For Aging Skin That Actually Works

  • Weakened Skin Barrier

    Declining estrogen thins the skin barrier, making skin more sensitive, reactive, and prone to irritation.

  • Collagen Loss

    Decreased collagen production leads to loss of firmness and elasticity, causing fine lines and wrinkles to deepen.

  • Slower Cell Renewal

    Cell turnover slows down, causing dead skin cells to build up, leaving skin dull and uneven with lingering dark spots.

  • Collagen Breakdown

    Overactive enzymes (MMPs) break down existing collagen, accelerating structural damage and leading to sagging and deep wrinkles.

That’s why Peptide Squad combines four classes of peptides, each designed to support aging skin in a different way.
4.7/5 based on 1,186+ verified reviews

See the Difference for Yourself

From real customers using the Glow Maker and Peptide Squad together consistently.

Love the Peptide Squad!

I was surprised at how much I love the Peptide Squad. It’s kinda spicy when you put it on - just a slight burn that lasts maybe 15 seconds, but enough that you realize it’s doing something. My face feels somewhat tighter and my complexion to me just looks a little better and more glowy.

Jennifer T.Verified Buyer

Absolutely LOVE

I’ve used a couple of other peptide serums over the years and this one beats all. I love how easily it goes on and does not leave a sticky residue.

Dawn F.Verified Buyer

Visible improvement

I do see that the prior lines on my neck & face (left, before) have smoothed & become less deep. I think that of the 4 products I've purchased from Maelove, this is my favorite.

Lisa G.Verified Buyer

Wonderful!

Great results from the “squad” of peptides. My skin has a bounce! No bad smell, pretty color and melts right into my skin. I love how I can use my 4 serums with hardly any wait time!! Thank you, Maelove! I love being comfortable enough to go make up free, it’s these products!!

Susan G.Verified Buyer

Peptides

I call it the blue stuff and I love it. I never do before and after, so I can't prove it's working, but I think it's helped slow the aging process down and protect my skin.

Debra W.Verified Buyer

Skin feeling youthful

At 64 I have had a challenge with trying to keep my skin from sagging and wrinkling. This helps. I can definitely tell a difference when I run out!

Kelly S.Verified Buyer

Love this product!

I se the peptide with the night serum. M 75urs old and live in Hawaii. I’ve been in the sun my whole life!! I love here products

Nancy B.Verified Buyer
Loved by Women 40+

Not All Wrinkle Serums Are Built for Changing Skin.

Feature
Peptide Squad
SkinCeuticals PTIOX
Price
$47.95
($600+ annual savings)
$150
Targets Collagen Production
Yes
Partially
Designed for Hormonal Skin Changes
Yes
No (General Anti-Aging)
4 Classes of Peptides
Yes (All Four)
2 types only
Vitamin C + Peptides Together Safely
Yes, Tested And Verified
Sensitive-Skin Optimized
Yes
Niacinamide, Ceramides, Panthenol
Vegan & Cruelty-free
Yes
No
Money-Back Guarantee
100 days (Industry-Leading Guarantee)
30 day website return policy

We’re serious about facts. Ask away.

Can't find your answer? Reach out to our team, we respond within 24 hours.

How does Peptide Squad compare to other peptide serums?

Most peptide serums on the market fall into one of two camps:

Single-peptide formulas: They include one or two peptides (usually Matrixyl or copper) at an effective concentration. These work, but they're only addressing one mechanism of aging.

Peptide cocktails: They list an assortment of different peptides on the label, which sounds impressive, but many lack published clinical studies, and there's often no clear rationale for why those specific peptides were combined.

What makes Peptide Squad different: We took a targeted approach: four peptides, each from a different class with a distinct mechanism of action, formulated at clinically effective concentrations.

  • Signal Peptides (Matrixyl 3000): Stimulate collagen production
  • Neurotransmitter Inhibitors (Argireline): Soften expression lines
  • Carrier Peptides (Copper Tripeptide-1): Deliver copper for collagen synthesis
  • Enzyme Inhibitors (Rice Peptides): Block collagen breakdown

Each one is backed by published clinical research. Together, they create synergy, attacking aging from multiple angles simultaneously for faster, more comprehensive results than any single peptide can deliver.

Unlike many peptide serums that feel heavy or sticky, ours absorbs in seconds. You get serious anti-aging power without the tacky residue or irritation.

What are the four classes of wrinkle-fighting peptides in Peptide Squad?

Each class of peptide fights aging through a different mechanism:

  • Signal Peptides (Matrixyl 3000): Tell your skin to build more collagen and elastin
  • Neurotransmitter-Inhibiting Peptides (Argireline): Relax expression lines by reducing muscle contractions
  • Carrier Peptides (Copper Tripeptide-1): Deliver copper to support collagen production and repair
  • Enzyme-Inhibiting Peptides (Rice Peptides): Block enzymes that break down collagen

By combining all four types, we're addressing aging from multiple angles simultaneously. This creates synergy - the peptides work better together than individually, leading to faster and better results.

How long would it take to see results?

First week: Your skin feels smoother, softer, and noticeably plumper to the touch. Makeup glides on without pilling or sliding because this absorbs so cleanly.

Weeks 4-8: This is the 'firming window.' Fine lines start to soften, and your skin feels more bouncy when you press on it.

The long game: This is where peptides really shine. You're not just treating existing damage - you're actively slowing down future aging by supporting your skin's structure every day.

The goal? In 10 years, look like you've aged only five. Use it daily to keep sending those rebuilding signals to your skin.

Can I use Peptide Squad with vitamin C and retinoids?

Yes, with other Maelove products.

Some people worry that copper peptides react with vitamin C and cause oxidation. That concern applies to free copper ions. Peptide Squad's copper is bound to a GHK peptide (Copper Tripeptide-1), a stable complex that occurs naturally in skin, so there's no free copper to react.

We've run internal stability tests confirming Peptide Squad does not cause oxidation of the vitamin C in Glow Maker, and does not degrade the retinoids in Stargaze or Moonlight.

Please keep in mind that we can only speak to our own formulas. We can't vouch for other brands' vitamin C, retinol, or peptide serums, since we don't know how they're formulated or whether they layer safely.

Is it safe to use Peptide Squad if I am pregnant or breastfeeding?

Yes. The actives in Peptide Squad, including peptides, niacinamide, panthenol, hyaluronic acid, natural moisturizing factors, ceramides, jojoba, and botanical extracts and actives such as allantoin, aloe, green tea, turmeric, madecassoside (found in cica) and bisabolol (found in chamomile), are all considered generally safe to use topically during pregnancy and lactation.

However, it is always advisable to check with your doctor regarding skincare products and ingredients, and to follow their advice.

  • Dermatologist-Tested
  • Safe for Sensitive Skin
  • Boosts Collagen Production
  • Made in the USA
4.7
Rated 4.7 out of 5 stars
Based on 1,186 reviews
Customers Talked About
1,186 reviews
  • SD
    Shannon D.
    Verified Buyer
    I recommend this product
    What are your skin concerns? Redness and sensitivity, Fine lines and wrinkles
    How old are you? 35-44
    What is your skin type? Dry
    Product Standouts Great texture, Easy To Use, Gentle, Great Ingredients, Hydrating
    Rated 5 out of 5 stars
    1 week ago
    I used a whole bottle and everyone says they notice

    Im legitimately impressed, for a topical i feel that it really worked really well. My skin is definitely brighter and less irritated, after my third child my skin has been soo touchy i cant even use eyeshadow without breaking into a rash but this made my skin clear and calm. My skin looks and feels plumper but the real change was my neck. My horizontal line was noticeably reduced and the fine lines around my eyes. The thin skin is just plumper! I ordered a second bottle and my mom bought one too! The bottle lasted me just about 40 days of applying twice a day.

    Before is on the left, after on the right. No makeup.

  • LG
    Lisa G.
    Verified Buyer
    I recommend this product
    What are your skin concerns? Fine lines and wrinkles, Sun Damage, Dark spots
    How old are you? 55+
    What is your skin type? Combination
    Product Standouts Great Ingredients
    Rated 4 out of 5 stars
    2 months ago
    Visible improvement

    I chose Maelove's peptide serum because of the quality actives that actually improve skin: several peptides, several ceramides and also Niacinamide, Panthenol & hyaluronic acid. I do see that the prior lines on my neck & face (left, before) have smoothed & become less deep. I think that of the 4 products I've purchased from Maelove, this is my favorite.

  • DF
    Dawn F.
    Verified Buyer
    I recommend this product
    What are your skin concerns? Sun Damage, Fine lines and wrinkles
    How old are you? 45-54
    What is your skin type? Dry
    Product Standouts Great texture, Easy To Use, Hydrating, Gentle
    Rated 5 out of 5 stars
    2 months ago
    Absolutely LOVE

    I’ve used a couple of other peptide serums over the years and this one beats all. I love how easily it goes on and does not leave a sticky residue.

  • LJ
    Lisa J. J.
    Verified Buyer
    I recommend this product
    What are your skin concerns? Acne and blemishes, Dryness, Redness and sensitivity, Dark spots, Sun Damage
    How old are you? 45-54
    What is your skin type? Dry
    Product Standouts Easy To Use, Hydrating, Gentle, Great Ingredients
    Rated 5 out of 5 stars
    3 months ago
    Peptide squad

    Loving this product. No break outs or skin irritations.

  • JT
    Jennifer T.
    Verified Buyer
    I recommend this product
    What are your skin concerns? Dryness, Fine lines and wrinkles
    How old are you? 45-54
    What is your skin type? Dry
    Product Standouts Great Ingredients, Great texture, Hydrating
    Rated 5 out of 5 stars
    7 months ago
    Love the Peptide Squad!

    I was surprised at how much I love the Peptide Squad. It’s kinda spicy when you put it on - just a slight burn that lasts maybe 15 seconds, but enough that you realize it’s doing something. My face feels somewhat tighter and my complexion to me just looks a little better and more glowy. I’ve only been using it about 1 month now. I’m also using Glow Maker & Moonlight. I’ve been very happy with all 3 products.